September 19, 2011

Miracle Transplant Allows Dying Man to Leave the Hospital Cancer-Free

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September 19, 2011
Bottom Line's Daily Health News
In This Issue...
  • Get a One Year Subscription to Health & Healing for Only $9.99!
  • Miracle Transplant Allows Dying Man to Leave the Hospital Cancer-Free
  • "I Cured My Acid Reflux... In My Kitchen!"
  • Castor Oil -- Thoroughly Modern Take on an Old-Fashioned Remedy

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Miracle Transplant Allows Dying Man to Leave the Hospital Cancer-Free

Imagine a patient with inoperable late-stage cancer of the trachea who is told that all treatment has failed and his tumor is now so large that it is about to block his windpipe. If we were watching this plot unfold at the movies, we would seem to be nearing the end of a very sad story. Then, in a plot twist that you usually see only on a cinema screen, doctors inform the man that there is one last chance. He can have a trachea transplant -- an operation with one very big catch. The trachea is not from a donor but rather it is man-made -- the first ever. To boost the chance that his body will accept the synthetic trachea, doctors are planning to "seed" or coat it with the patient’s own stem cells, which should -- hopefully -- keep his body from rejecting it. With nothing left to lose, the patient agrees to give it a try -- and a month after the surgery he is alive, well and able to walk out of the hospital, cancer-free.

This is all real, not from a movie. One very rarely hears of an outcome this positive, and I wanted to know whether it was a fluke -- and what it might mean for others in similarly frightening circumstances.

A Windpipe Made of Plastic

I called David Green, president and director of Harvard Bioscience, Inc., which produced the device (called a bioreactor) used to seed the stem cells that covered the trachea. Green explained that tracheal cancer is rare, but with symptoms similar to many ordinary bronchial conditions, it often is not diagnosed until it is too late. This patient was fortunate in that the cancer had not spread. The larynx and pharynx -- situated just millimeters above the trachea -- were both healthy, as were his lungs.

The material doctors used to make the inner structure of the trachea -- called a scaffold -- was a plastic polymer, a porous and spongy material flexible enough for the main part of the tubelike organ but that could also be made thicker and stronger to create the rings of the windpipe for structural stability. To harvest the patient’s stem cells, doctors withdrew two cups of bone marrow from his hip bone, which is a standard site to obtain stem cells, says Green. Seeding the stem cells onto the trachea was a two-day process that involved pouring the cells over the scaffold and literally soaking it in them. Green told me there are pockets in the scaffold’s porous material that are just the right size for the stem cells, making it "feel like home to them." Once the trachea was delivered to the operating room at the Karolinska University Hospital in Sweden, where the transplant was performed, surgeons were able to trim it to make a custom fit for the patient, says Green. The whole process took less than a week.

A Giant Leap Forward

This groundbreaking surgery has implications on several fronts that could change the face of treatment for a variety of cancers. Green says that the technique for building the scaffold likely could be adapted to build other tubular structures including the esophagus and the ureters, which carry urine from the kidneys to the bladder. With synthetic scaffolds available, there would no longer be the need for donor parts, and the long, stressful wait that has always been a necessary part of the transplant process would be greatly lessened. Another huge benefit: By seeding scaffolds with patients’ own stem cells, those individuals may be spared a lifetime of taking antirejection drugs and dealing with a compromised immune system. In fact, we already have evidence that the stem-cell seeding works based on a donor-trachea surgery performed in Spain in 2008. In what was then a groundbreaking step, doctors seeded the donor’s trachea with the patient’s stem cells. Three years later, that patient is alive and well and doesn’t have to take antirejection drugs.

Watching the Future Change

In light of the ongoing controversies surrounding the use of embryonic stem cells, it is thrilling to see what science is now achieving without them. Clearly we are just starting down the path of both stem-cell treatment and the possibilities of man-made body parts, and the future looks bright indeed. In fact, doctors have announced that they hope to begin transplanting synthetic tracheas to patients in the US for the first time in the coming year.

Source(s):

David Green, president, Harvard Biosciences, Inc., a manufacturer and marketer of specialized products used for regenerative medicine, Holliston, Massachusetts. www.HarvardBioscience.com.


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Castor Oil -- Thoroughly Modern Take on an Old-Fashioned Remedy

I was quite a bookworm when I was a girl -- and I remember reading about many a storybook heroine who had to swallow a daily dose of castor oil for her health. Ugh! I thought it sounded awful -- and I still do -- but as it turns out, you don’t have to swallow the stuff (and in fact, you shouldn’t) for it to do a world of good!

I was reminded that this would make a great story for Daily Health News readers when a good friend told me that her naturopathic physician had prescribed castor oil packs to ease the pain and swelling of her twisted ankle. It worked so well that she was back to the gym in no time at all -- no drugs, no side effects. I decided it was time to take a new look at this old-fashioned remedy.

Heals from the Outside In

As I often do with questions like this one, I called Daily Health News contributing medical editor Andrew L. Rubman, ND, to see what he had to say -- and I learned that he is quite a fan of castor oil. He told me that it is a versatile remedy that continues to offer a wide array of benefits today, just as it has for thousands of years.

Castor oil, which looks and smells like gooey glycerin, is an oily extract that comes from the Ricinus communis plant native to India and Africa. In days of yore, parents routinely dosed girls and boys with a teaspoon or two in order to prevent constipation -- it also was thought to cure headaches. Today internal use is considered unwise because of its strong, often irritating laxative effect... but external application of a castor oil "pack" -- meaning a cloth soaked in the oil -- can help in all sorts of ways.

The Wonder Cure?

Castor oil packs mold comfortably to the body... stay warm much longer than hot water... and deeply and gently stimulate circulation, removing inflammation from underlying organs and tissues (e.g., the liver, intestines, tendons, ligaments). You can buy castor oil packs inexpensively at most drugstores or, as we explain later, you can make your own.

Dr. Rubman gave me a rundown of his favorite uses...
  • Soothing arthritis pain. To relieve that ache in your knee or hip, apply a castor oil pack that is roughly the same temperature as a hot bath (105°F). Put the pack directly on the area that hurts, cover with a plastic wrap of some sort (a ziplock bag is a good choice) and then cover that with a hot water bottle or electric heating pad to maintain the temperature. Leave it in place for about 20 to 30 minutes. Repeat every few hours or so. For long-standing conditions, it may be more practical to do this once a day and leave the pack in place for the better part of an hour, Dr. Rubman said.
  • Reducing swelling and inflammation. A castor oil pack is helpful in soothing a muscle strain or a bruise.
  • Relieving congestion. If you have a nagging cold, cough or bronchitis, place the castor oil pack on your chest for quick relief.
  • Making a boil disappear. Before you schedule an appointment to have your doctor lance a boil, try using a castor oil pack, which will encourage the boil to open and drain. For this purpose, make a smaller pack... make it a bit hotter... and use for shorter periods of time, Dr. Rubman suggests.
  • Stimulating your liver and gallbladder. For most of us, our less-than-ideal lifestyles -- poor diet, multiple medications, exposure to environmental toxins, etc. -- take a toll on these hard-working organs. Dr. Rubman told me that centuries of folk wisdom suggest that you can help them function better by applying a warm castor oil pack to the right side of your abdomen -- supposedly the heat transfers to the liver and increases circulation there. Castor oil’s viscosity creates a deep and lasting heat. What to do: Dr. Rubman suggests placing the pack over an area about the size of a washcloth, centered on the bottom of your rib cage or between the rib cage and the top of hip bone.
If you’d like to make your own castor oil pack, buy castor oil (available at pharmacies) and follow these simple instructions from Dr. Rubman:
  • Pour enough castor oil to cover the cloth you are going to use (such as a clean washcloth) into a pan, ovenproof or microwavable bowl and heat on the stove, in the oven or microwave to hot bathwater temperature (about 105°F). Take care to not leave it in too long or it will get too hot and you may get burned when you remove it.
  • Soak the cloth in the warm castor oil until it is saturated.
  • Wipe excess oil off the cloth (so it’s not dripping) and place the pack on the affected area of your body... cover the pack with a sheet of plastic wrap... and cover that with a heating pad or hot water bottle to keep it warm. As explained above, leave on for 20 to 30 minutes twice a day -- or, for chronic conditions, up to an hour, once a day. Rest during this time.
  • When you are finished using the pack, wring as much oil as you can out of the cloth and cover it in plastic, such as by placing it into a resealable plastic bag, until its next use.
Castor Oil Packs -- Making Them Last

Between uses, store castor oil packs in the refrigerator. When reusing, refresh the packs with additional oil as needed. Dispose of them after about 10 (commercial packs) to 20 (homemade ones) applications. The homemade packs tend to retain the embedded oil longer, Dr. Rubman said, adding they should be discarded when they no longer feel sticky.

Hot tip: Dr. Rubman told me that you can intensify the effectiveness of a castor oil pack by sprinkling a teaspoon of cayenne (hot pepper) powder onto the pack (after you’ve heated it) on the same side you apply to your skin. He explained that the capsaicin in the hot pepper is a pain reliever that increases the stimulating effect on circulation. (Wash your hands with soap and water afterward -- you don’t want to get this stuff in your eyes or, frankly, on any other sensitive place, such as on mucous membranes!)

Dr. Rubman had another bit of practical advice -- he said that castor oil has a tacky, gluelike texture and that handling it can be a messy business. So make sure when you are using the pack that plastic covers it completely -- to avoid staining clothing, bedding or upholstery with castor oil.

Source(s):

Andrew L. Rubman, ND, founder and director, Southbury Clinic for Traditional Medicines, Southbury, Connecticut. www.SouthburyClinic.com.


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Be well,


Carole Jackson
Bottom Line's Daily Health News


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